An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus
Identifieur interne : 002055 ( Main/Exploration ); précédent : 002054; suivant : 002056An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus
Auteurs : Yanfeng Yao ; Linlin Bao ; Wei Deng ; Lili Xu ; Fengdi Li ; Qi Lv ; Pin Yu ; Ting Chen ; Yanfeng Xu ; Hua Zhu ; Jing Yuan ; Songzhi Gu ; Qiang Wei ; Honglin Chen [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine] ; Chuan QinSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Infections à coronavirus.
- physiologie : Coronavirus.
- sang : Anticorps antiviraux, Anticorps neutralisants.
- virologie : Infections à coronavirus.
- Animaux, Histocytochimie, Macaca mulatta, Modèles animaux de maladie humaine, Réplication virale.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral.
- pathology : Coronavirus Infections.
- physiology : Coronavirus.
- virology : Coronavirus Infections.
- Animals, Disease Models, Animal, Histocytochemistry, Macaca mulatta, Virus Replication.
Abstract
In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
Url:
DOI: 10.1093/infdis/jit590
PubMed: 24218506
PubMed Central: 7107340
Affiliations:
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Le document en format XML
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type="wicri:Area/Main/Exploration">002055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus</title><author><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Xu, Lili" sort="Xu, Lili" uniqKey="Xu L" first="Lili" last="Xu">Lili Xu</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Li, Fengdi" sort="Li, Fengdi" uniqKey="Li F" first="Fengdi" last="Li">Fengdi Li</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Lv, Qi" sort="Lv, Qi" uniqKey="Lv Q" first="Qi" last="Lv">Qi Lv</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yu, Pin" sort="Yu, Pin" uniqKey="Yu P" first="Pin" last="Yu">Pin Yu</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Ting" sort="Chen, Ting" uniqKey="Chen T" first="Ting" last="Chen">Ting Chen</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Xu, Yanfeng" sort="Xu, Yanfeng" uniqKey="Xu Y" first="Yanfeng" last="Xu">Yanfeng Xu</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Yuan, Jing" sort="Yuan, Jing" uniqKey="Yuan J" first="Jing" last="Yuan">Jing Yuan</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Gu, Songzhi" sort="Gu, Songzhi" uniqKey="Gu S" first="Songzhi" last="Gu">Songzhi Gu</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Wei, Qiang" sort="Wei, Qiang" uniqKey="Wei Q" first="Qiang" last="Wei">Qiang Wei</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author><author><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology and the Research Centre of Infection and Immunology</addr-line>,<institution>University of Hong Kong</institution>,<addr-line>Pokfulam</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:aff id="af2"><addr-line>State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology and the Research Centre of Infection and Immunology</addr-line>,<institution>University of Hong Kong</institution>,<addr-line>Pokfulam</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:aff id="af1"><addr-line>Key Laboratory of Human Disease Comparative Medicine, Ministry of Health</addr-line>,<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences and Comparative Medicine Center, Peking Union Medical College</institution>,<addr-line>Beijing</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Coronavirus (physiology)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Disease Models, Animal</term><term>Histocytochemistry</term><term>Macaca mulatta</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Anticorps neutralisants (sang)</term><term>Coronavirus (physiologie)</term><term>Histocytochimie</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (virologie)</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Réplication virale</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term><term>Anticorps neutralisants</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Histocytochemistry</term><term>Macaca mulatta</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Histocytochimie</term><term>Macaca mulatta</term><term>Modèles animaux de maladie humaine</term><term>Réplication virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Cheng, Vc" uniqKey="Cheng V">VC Cheng</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Js" uniqKey="Peiris J">JS Peiris</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL 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Zumla</name></author><author><name sortKey="Al Hakeem, Rf" uniqKey="Al Hakeem R">RF Al-Hakeem</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Stephens, Gm" uniqKey="Stephens G">GM Stephens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Prescott, J" uniqKey="Prescott J">J Prescott</name></author><author><name sortKey="Baseler, L" uniqKey="Baseler L">L Baseler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weinfurter, Jt" uniqKey="Weinfurter J">JT 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Costabel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Seilmaier, M" uniqKey="Seilmaier M">M Seilmaier</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guery, B" uniqKey="Guery B">B Guery</name></author><author><name sortKey="Poissy, J" uniqKey="Poissy J">J Poissy</name></author><author><name sortKey="El Mansouf, L" uniqKey="El Mansouf L">L el Mansouf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Choi, Gk" uniqKey="Choi G">GK Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><name sortKey="Chen, Ting" sort="Chen, Ting" uniqKey="Chen T" first="Ting" last="Chen">Ting Chen</name><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><name sortKey="Gu, Songzhi" sort="Gu, Songzhi" uniqKey="Gu S" first="Songzhi" last="Gu">Songzhi Gu</name><name sortKey="Li, Fengdi" sort="Li, Fengdi" uniqKey="Li F" first="Fengdi" last="Li">Fengdi Li</name><name sortKey="Lv, Qi" sort="Lv, Qi" uniqKey="Lv Q" first="Qi" last="Lv">Qi Lv</name><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><name sortKey="Wei, Qiang" sort="Wei, Qiang" uniqKey="Wei Q" first="Qiang" last="Wei">Qiang Wei</name><name sortKey="Xu, Lili" sort="Xu, Lili" uniqKey="Xu L" first="Lili" last="Xu">Lili Xu</name><name sortKey="Xu, Yanfeng" sort="Xu, Yanfeng" uniqKey="Xu Y" first="Yanfeng" last="Xu">Yanfeng Xu</name><name sortKey="Yao, Yanfeng" sort="Yao, Yanfeng" uniqKey="Yao Y" first="Yanfeng" last="Yao">Yanfeng Yao</name><name sortKey="Yu, Pin" sort="Yu, Pin" uniqKey="Yu P" first="Pin" last="Yu">Pin Yu</name><name sortKey="Yuan, Jing" sort="Yuan, Jing" uniqKey="Yuan J" first="Jing" last="Yuan">Jing Yuan</name><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Honglin" sort="Chen, Honglin" uniqKey="Chen H" first="Honglin" last="Chen">Honglin Chen</name></noRegion><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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